Development and in vitro evaluation of fast dissolving tablets of imipramine

Abstract

Fast dissolving tablet dissolve rapidly in the mouth to be swallowed without the aid of water. Because of the strong public interest, a number of products have already been commercialized. The aim of the present investigation is to formulate fast dissolving tablets of imipramine, a tricyclic antidepressant and water soluble, by direct compression method. Two superdisintegrants viz, crospovidone and croscarmellose sodium (5%, 6%) with different binders viz, pvp k-30 and pregelatinized starch (3%) were used. The prepared batches of tablets were evaluated for hardness, friability, weight variation, disintegration, wetting time, drug content and in vitro dissolution studies. Based on evaluating parameters, Formulation prepared by using 5% croscarmellose sodium with 3% PVP K30 was selected as optimized formulation. Stability studies were carried out at 25°C / 60% RH and 40°C / 75% RH for optimized formulation for 3 months. Stability studies on the optimized formulation indicated that there was no significant change found in physical appearance, disintegration time and wetting time of the tablets. Finally it was concluded that fast dissolving tablets of imipramine can be successfully formulated by superdisintegrant addition method with improved patient compliance.