Evaluation of hepatoprotective effect of polyherbal formulation - Livomyn

Abstract

The liver is the most important organ and has great capacity to detoxify and synthesize useful substances. Therefore liver diseases like hepatic fibrosis, liver cirrhosis, hepatitis and hepatocellular carcinoma are of global concern. In absence of reliable hepatoprotective agent in modern medicine the herbal formulations are the most preferred therapy for liver injury. The present study investigates the efficacy of one such polyherbal formulation – Livomyn as a hepatoprotective formula against ethanol, CCl₄ and galactosamine induced hepatotoxicity in Wistar rats. The evaluation of blood serum parameters exhibits significant reduction in the levels of albumin, bilirubin, SGOT, SGPT, LPO, alkaline phosphate and cholesterol whereas significant increase in Total protein and reduced GSH levels in Livomyn treated groups. The hepatoprotective effect is attributed to synergistic effect of potent antioxidant and hepatoprotective property of various medicinal plant extracts in Livomyn formulation.