Protective Role of Pitcher of Nepenthes khasiana Hook against Dexamethazone Induced Hyperlipidemia and Insulin Resistance in Rats

Abstract

The present research was made to investigate the potential hypoglycemic and hypolipidemic effect of Nepenthes khasiana Hook in Dexamethazone-induced Hyperlipidemia and Insulin Resistance in Rats. Hypoglycemic and hypolipidemic effect of pitcher extract of Nepenthes khasiana Hook was tested at two different doses of 250 & 500 mg/kg p.o. On day 11 of treatment, blood was collected for the estimation of serum glucose and lipid parameters. Pitcher extract was compared with standard Glibenclamide at a dose of 500 mcg/kg p.o. pitcher extract and Glibenclamide significantly decreased (P<0.05) dexamethazone induced elevation of serum glucose when compared to disease control group. Pitcher extract at a dose of 500 mg/kg showed better activity than standard. The present study indicates that pitcher extract of Nepenthes khasiana Hook show significant glucose and lipid lowering activity.