Design and in vitro characterization of Amoxicillin loaded sepia nanoparticles

Abstract

The objective of the present work was to investigate the preparation of sepia nanoparticles as a potential drug carrier, amoxicillin Trihydrate as a model drug. The sepia nanoparticles were prepared by using the controlled gellification process. In this research work, different drug and polymer ratios were used. The prepared nanoparticles were evaluated to assess the various parameters such as drug content analysis, particle size analysis (SEM Analysis), Zeta potential analysis, In-Vitro drug release and stability studies. The particle size of prepared nanoparticles was found to be 500nm. The drug content analysis of all the prepared formulations was estimated in the range of 57.34 ± 0.10 to 65.33 ± 0.11 %. The zeta potential of the sepia nanoparticles was estimated as 69mv. The Cumulative percentage drug release of the third formulation was found to be 90.36 %. By observing in- Vitro drug release results of all formulations, we concluded that, AMN3 formulation was found to be the best formulation with a higher Cumulative percentage drug release.