Molecular dynamic properties and Insilico screening of neuroprotective activity of Clitoria ternatea against Glutamate receptors

Gejalakshmi S (1) , Harikrishnan N (2) , Anas Mohamied (3)
(1) Faculty of Pharmacy, Dr.M.G.R. Educational and Research Institute Velappanchavadi, Chennai-77, Tamil Nadu, India, India ,
(2) Faculty of Pharmacy, Dr.M.G.R. Educational and Research Institute Velappanchavadi, Chennai-77, Tamil Nadu, India, India ,
(3) Faculty of Pharmacy, Omar Al Mukthar University, Al-Bayda, Libya, Libya

Abstract

Multiple sclerosis is a popular autoimmune disease attack mainly the Central nervous system. It attacks the age group of people from 20-50, mostly women are attacked than men. During multiple sclerosis, takes place along with axon damage and paralytic effect. Various symptoms of multiple sclerosis include muscle weakness, weak reflexes, muscle spasm, movement difficulty. Moreover, treatment of multiple sclerosis drugs includes various side effects. Medicinal plants possess many of greater therapeutic value and many of effective to treat multiple sclerosis, Chemical constituents exhibit its effect over multiple sclerosis by inhibiting many proteins involved in . Molecular docking is a computational design approach which facilitates the best molecule from a group which may bind with the highest affinity with the intended target by providing a biological system. This process enables on the basis of the specific algorithm and involves a scoring function in order to rank molecules that fit the target. The study has been made to investigate the potential of from -inositol and as inhibitors of receptors. Drug likeness property determined based on .com. The affinities of those selected chemical constituents over various receptor were studied for scoring function. Receptors with PDB code 1EQ8,4E0W,3KR2 were chosen to dock against the chemical constituent chemical constituent in Clitoria and scoring function was found to be -3.45,-4.56, -5.67kcal/.

Full text article

Generated from XML file

References

Bowling, A. C. 2018. Multiple Sclerosis and Related Disorders: Diagnosis, Medical Management and Rehabilitation. Demos, pages 243–249.

Camiña-Tato, M., Fernández, M., Morcillo-Suárez, C., Navarro, A., Julià, E., Edo, M. C., Montalban, X., Comabella, M. 2010. Genetic association of CASP8 polymorphisms with primary progressive multiple sclerosis. Journal of Neuroimmunology, 222(1- 2):70–75.

Jain, N. N., Ohal, C. C., Shroff, S. K., Bhutada, R. H., Somani, R. S., Kasture, V. S. 2003. Clitoria ternatea and the CNS. Pharmacology Biochemistry and Behavior, 75(3):529–536.

Jiang, F., Frederick, T. J., Wood, T. L. 2001. IGF-I Synergizes with FGF-2 to Stimulate Oligodendrocyte Progenitor Entry into the Cell Cycle. Developmental Biology, 232(2):414–423.

Mahad, D. J., Lawry, J., Howell, S. J., Woodroofe, M. N. 2003. Longitudinal study of chemokine receptor expression on peripheral lymphocytes in multiple sclerosis: CXCR3 upregulation is associated with relapse. Multiple Sclerosis Journal, 9(2):189–198.

Mitsikostas, D. D., Goodin, D. S. 2017. Comparing the efficacy of disease-modifying therapies in multiple sclerosis. Multiple Sclerosis and Related Disorders, 18:109–116.

Nave, K. A. 2010. Myelination and support of axonal integrity by glia. Nature, 468(7321):244–252.

Nave, K.A., Trapp, B. D. 2008. Axon-Glial Signaling and the Glial Support of Axon Function. Annual Review of Neuroscience, 31(1):535–561.

Pati, A. P., Patil, V. R. 2011. Comparative evaluation of hepatoprotective potential of roots of blue and white flowered varieties of Clitoria ternatea Linn. Pelagia Research Library. Der Pharmacia Sinica, 2:128–137.

Shende, V., Sahane, R., Lawar, M., Hamdulay, N., Langote, H. 2012. Evaluation of anti-compulsive effect of ethanolic extract of Clitoria ternatea in mice. Asian Journal of Pharmaceutical and Clinical Research, 5(3):120–123.

Authors

Gejalakshmi S
gejampharm@gmail.com (Primary Contact)
Harikrishnan N
Anas Mohamied
Gejalakshmi S, Harikrishnan N, & Anas Mohamied. (2020). Molecular dynamic properties and Insilico screening of neuroprotective activity of Clitoria ternatea against Glutamate receptors. International Journal of Research in Pharmaceutical Sciences, 11(4), 7043–7047. Retrieved from https://ijrps.com/home/article/view/178

Article Details

No Related Submission Found