A Review Study on Cellulitis

Hemalatha C N; Jagadeesan B; Janani N; Aniesh Kumar A; Harinathan R; Harikrishnan N

Hemalatha C N ⁽¹⁾ , Jagadeesan B ⁽²⁾ , Janani N ⁽³⁾ , Aniesh Kumar A ⁽⁴⁾ , Harinathan R ⁽⁵⁾ , Harikrishnan N ⁽⁶⁾

(1) Faculty of Pharmacy, Dr.M.G. R Educational and Research Institute, Velappanchavadi, Chennai, Tamil Nadu, India, India ,

(2) Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Porur, Chennai, Tamil Nadu, India, India ,

(3) Faculty of Pharmacy, Dr.M.G. R Educational and Research Institute, Velappanchavadi, Chennai, Tamil Nadu, India, India ,

(4) Faculty of Pharmacy, Dr.M.G. R Educational and Research Institute, Velappanchavadi, Chennai, Tamil Nadu, India, India ,

(5) Faculty of Pharmacy, Dr.M.G. R Educational and Research Institute, Velappanchavadi, Chennai, Tamil Nadu, India, India ,

(6) Faculty of Pharmacy, Dr.M.G. R Educational and Research Institute, Velappanchavadi, Chennai, Tamil Nadu, India, India

Issue
Vol. 12 No. 2 (2021): Volume 12 Issue 2

Keywords:

Cellulitis, streptococci aureus, CT scan, Non – Steroidal Anti-Inflammatory Drugs, Clindamycin, Dicloxacillin

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Abstract

Cellulitis is a clinical condition which is characterised by reddishness, soreness, localized pain, erythema, swelling and formation of abscess in the leg, pyrexia and an increase in the heartbeat. It is the infection of the sub-cutaneous tissue and dermal layer usually found complicating a wound or ulcer. It is considered an infectious disease as it causes morbidity and mortality. It is also called skin diseases, as the skin is involved and lacks sharp demarcation from uninvolved skin. Cellulitis spreads rapidly and is pyogenic in nature and is frequently associated with lymphangitis and fever. Streptococci (streptococci pyogenes) and staphylococcus aureus are the two species which causes cellulitis. Five types of cellulitis can be classified they are facial cellulitis, periorbital cellulitis, breast cellulitis, perianal cellulitis. Diagnosis of cellulitis is based on morphological features of the lesion and a CT scan is required for determining cellulitis. By the visual inspection, the cellulitis is spotted. The common risk factor for cellulitis is oedema. If the cellulitis patient has Diabetes Mellitus or injury in the skin or any inflammation in the liver, they are considered to be in a dangerous state. Non-Steroidal Anti-Inflammatory Drugs are prescribed to decrease the clinical features. Clindamycin, Dicloxacillin are antibiotics that are administered to cure cellulitis. This review discusses the general information regarding cellulitis, its clinical indications, pathophysiology, microbiology and its treatment.

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References

Abrahamian, F.M., Goldstein, E.J.C. 2011. Microbiology of Animal Bite Wound Infections. Clinical Microbiology Reviews, 24(2):231–246. ISSN: 0893-8512.

Bruun, T., Oppegaard, O., Kittang, B.R., Mylvaganam, H., Langeland, N., Skrede, S. 2016. Etiology of Cellulitis and Clinical Prediction of Streptococcal Disease: A Prospective Study. Open Forum Infectious Diseases, 3:181–181. ISSN: 2328-8957.

Chiras, M. 2010. Staphylococcus aureus is the most common identified cause of cellulitis: a systematic review. Epidemiol Infect, 138(3):313–330.

Chosidow, O. 1991. Nonsteroidal anti-inflammatory drugs in cellulitis: a cautionary note. Archives of Dermatology, 127(12):1845–1846. ISSN: 0003-987X.

Christensen, K.L.Y., Holman, R.C., Steiner, C.A., Sejvar, J.J., Stoll, B.J., Schonberger, L.B. 2009. Infectious Disease Hospitalizations in the United States. Clinical Infectious Diseases, 49(7):1025– 1035. ISSN:1058-4838, 1537-6591.

Cranendonk, D.R., Lavrijsen, A.P.M., Prins, J.M., Wiersinga, W.J. 2017. Cellulitis: Current insights into pathophysiology and clinical management. Neth J Med, 75(9):20–20.

Daum, R.S. 2007. Skin and Soft-Tissue Infections Caused by Methicillin-Resistant Staphylococcus aureus. New England Journal of Medicine, 357(4):380–390. ISSN: 0028-4793, 1533-4406.

Fleisher, G., Ludwig, S. 1980. Cellulitis: A prospective study. Ann Emerg Med, 9(5):80380–80385.

Ginsberg, M.B. 1981. Cellulitis: analysis of 101 cases and review of the literature. South Med J, 74(5):20– 20.

Griegord, R., Orengoif, W. 1995. Dog, cat, and human bites: A review. J Am Acad Dermatol, 33(6):90296– 90297.

Gundersoncg, M. 2012. A systematic review of bacteremias in cellulitis and erysipelas. J Infect, 64(2):148–55.

Karppelinm, S., Vuopio-Varkilaj 2010. Factors pre-disposing to acute and recurrent bacterial non-necrotizing cellulitis in hospitalized patients: a prospective case-control study. Clin Microbiol Infect, 16(6):729–763.

Levell, N.J., Wingfield, C.G., Garioch, J.J. 2011. Severe lower limb cellulitis is best diagnosed by dermatologists and managed with shared care between primary and secondary care. Br J Dermatol, 164(6):1326–1354.

Linder, K. A., Malani, P. N. 2017. Cellulitis. JAMA Patient Page, 317:2142–2142. ISSN: 0098-7484.

Madaras-Kellykj, Remingtonre, Oliphantcm, Sloankl, B. 2008. Efficacy of oral β-lactam versus non-β- lactam treatment of uncomplicated cellulitis. Am J Med, 121(5):419–425.

Maitre, S. 2006. Cellulitis: Definition, Etiology, Diagnosis and Treatment. AMA Journal of Ethics, 8(12):831–833.

Raff, A.B., Kroshinsky, D. 2016. Cellulitis: A Review. JAMA, 316(3):325–362.

Thomas, K.S., Crook, A.M., Nunn, A.J., Foster, K.A., Mason, J.M., Chalmers, J.R. 2013. Penicillin to prevent recurrent leg cellulitis. N Engl J Med, 368(18):1695–703.

Yarbrough, P.M., Kukhareva, P.V., Spivak, E.S., Hopkins, C., Kawamoto, K. 2015. Evidence-based care pathway for cellulitis improves process, clinical, and cost outcomes. Journal of Hospital Medicine, 10(12):780–786. ISSN: 1553-5592.