An Overview of Novel Corona Virus 2019-nCoV and their Clinical and Immune Responses

Sheetal Devi (1) , Manish Kumar (2) , Prabhat Kumar Upadhyay (3) , Anuj Malik (4) , Beena Kumari (5) , Raj Singh (6) , Anil Kumar (7) , Pandurangan A (8)
(1) M. M. College of Pharmacy, Maharishi Markandeshwar (Deemed to Be University) Mullana, Ambala, Haryana, India, India ,
(2) M. M. College of Pharmacy, Maharishi Markandeshwar (Deemed to Be University) Mullana, Ambala, Haryana, India, India ,
(3) Institute of Pharmaceutical Research, GLA University, Mathura-281406, Uttar Pradesh, India, India ,
(4) M. M. College of Pharmacy, Maharishi Markandeshwar (Deemed to Be University) Mullana, Ambala, Haryana, India, India ,
(5) Department of Pharmaceutical Sciences, Indira Gandhi University, Meerpur, Rewari, Haryana, India, India ,
(6) Department of Biotechnology, MMES-2, Mullana, Ambala, Haryana, India, India ,
(7) Guru Jambheswar University of Science and Technology, Hisar, Haryana, India, India ,
(8) M. M. College of Pharmacy, Maharishi Markandeshwar (Deemed to Be University) Mullana, Ambala, Haryana, India, India

Abstract

The novel virus such as corona virus 2019 is the main cause of the disease that is declared by the WHO (World Health Origination). Some other virus similar to this virus were also discovered in initial year of 21th century such as SARS-CoV in 2003, HCoV NL63 in 2004, HKU1 in 2005, MERS-CoV in 2012, and SARS-CoV-2 in 2019. The first few cases of covid-19 were detected from direct contact to the infected animal to human which is also called as animal to human transmission. Due to direct exposure of this virus to infected animals the human to human transmission of the virus is as well possible, which is also likely to be consider and measured as core form of transmission. According to the reports of WHO by 26 February 2020, patients suffering from COVID-19 reduced gradually in China but rapidly increased in countries like Italy, Iran and South Korea. The infection caused by the COVID 19 is detected by looking at the symptoms and it ultimately confirmed by the reverse transcription polymerase chain reaction (rRT-PCR) of infected secretions with 71% sensitivity and computed tomography scan with 98%.  Pharmacological demonstrating dependent on observed drug absorptions and in vitro drug testing propose that prophylaxis with hydroxychloroquine at affirmed portions could anticipate SARS-CoV-2 contamination and improve viral shedding. Clinical preliminaries of hydroxychloroquine treatment for COVID-19 pneumonia are in progress in China (NCT04261517 and NCT04307693).

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Authors

Sheetal Devi
Manish Kumar
manish_singh17@rediffmail.com (Primary Contact)
Prabhat Kumar Upadhyay
Anuj Malik
Beena Kumari
Raj Singh
Anil Kumar
Pandurangan A
Sheetal Devi, Manish Kumar, Prabhat Kumar Upadhyay, Anuj Malik, Beena Kumari, Raj Singh, Anil Kumar, & Pandurangan A. (2020). An Overview of Novel Corona Virus 2019-nCoV and their Clinical and Immune Responses. International Journal of Research in Pharmaceutical Sciences, 11((SPL 1), 62–67. Retrieved from https://ijrps.com/home/article/view/1360

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