Effectiveness of amikacin administered by autoinjector compared to manual injection on infected excision wound model of Wistar rats

Anitha Roy (1) , Geetha R V (2) , Anitha Magesh (3) , Senthilkumar Sivanesan (4) , Vijayaraghavan R (5)
(1) Department of Pharmacology, Saveetha Dental College, SIMATS, Tamil Nadu, India, India ,
(2) Department of Microbiology, Saveetha Dental College, SIMATS, Tamil Nadu, India, India ,
(3) Department of Research and Development, Saveetha Medical College, SIMATS, Tamil Nadu, India, India ,
(4) Department of Research and Development, Saveetha Medical College, SIMATS, Tamil Nadu, India, India ,
(5) Department of Research and Development, Saveetha Medical College, SIMATS, Tamil Nadu, India, India

Abstract

To evaluate the effectiveness of amikacin administered by autoinjector compared to manual injection on infected excision wound model of Wistar rats. Randomly bred 14 Wistar rats of either sex weighing 180 to 230 g were used for the present study. The study has the approval of the Institutional Animal Ethical Committee. Pseudomonas aeruginosa was used for infecting the wounds. 1 mL of blood was withdrawn aseptically from the orbital sinus under isoflurane anaesthesia, and the biochemical parameters were carried out. All results were expressed as mean ± SEM, and the results were compared statistically by one-way ANOVA using Sigma Plot 13. P-value < 0.05 was considered statistically significant. The biochemical parameters in the study was more or less similar. The infected rats treated with amikacin showed faster wound contraction compared to control. This study concludes the effectiveness of amikacin administered through autoinjectors and manual injection in infected excision wound model as similar. Therefore, amikacin autoinjector is a better choice to manual injection to overcome from wound infections if it is administered at the right time in case of emergency or whenever required. Injury and wound infection are common in natural and manmade disasters. Serious bacterial wound infections are a potential threat to open injuries. As accessibility to the primary health centre or hospital may not be easy or possible during disasters and to overcome such a situation, an antibacterial autoinjector would be useful.

Full text article

Generated from XML file

Authors

Anitha Roy
anitharoy2015@gmail.com (Primary Contact)
Geetha R V
Anitha Magesh
Senthilkumar Sivanesan
Vijayaraghavan R
Anitha Roy, Geetha R V, Anitha Magesh, Senthilkumar Sivanesan, & Vijayaraghavan R. (2020). Effectiveness of amikacin administered by autoinjector compared to manual injection on infected excision wound model of Wistar rats. International Journal of Research in Pharmaceutical Sciences, 11(4), 5701–5707. Retrieved from https://ijrps.com/home/article/view/1147

Article Details

Most read articles by the same author(s)

1 2 3 4 > >> 
No Related Submission Found