Effectiveness of amikacin administered by autoinjector compared to manual injection on infected excision wound model of Wistar rats

Abstract

To evaluate the effectiveness of amikacin administered by autoinjector compared to manual injection on infected excision wound model of Wistar rats. Randomly bred 14 Wistar rats of either sex weighing 180 to 230 g were used for the present study. The study has the approval of the Institutional Animal Ethical Committee. Pseudomonas aeruginosa was used for infecting the wounds. 1 mL of blood was withdrawn aseptically from the orbital sinus under isoflurane anaesthesia, and the biochemical parameters were carried out. All results were expressed as mean ± SEM, and the results were compared statistically by one-way ANOVA using Sigma Plot 13. P-value < 0.05 was considered statistically significant. The biochemical parameters in the study was more or less similar. The infected rats treated with amikacin showed faster wound contraction compared to control. This study concludes the effectiveness of amikacin administered through autoinjectors and manual injection in infected excision wound model as similar. Therefore, amikacin autoinjector is a better choice to manual injection to overcome from wound infections if it is administered at the right time in case of emergency or whenever required. Injury and wound infection are common in natural and manmade disasters. Serious bacterial wound infections are a potential threat to open injuries. As accessibility to the primary health centre or hospital may not be easy or possible during disasters and to overcome such a situation, an antibacterial autoinjector would be useful.