Bones have a numerous significant functions in the body such as supporting and protecting various organs of the body. Osteoporosis is a disease of bone characterized by low bone mass and micro-architectural deterioration of bone tissue, that leads to enhanced bone fragility and increased likelihood of fractures. Osteoporosis may be caused due to lower than the normal peak bone mass. Low bone mass results in faster rate of bone porosity and predisposes to osteoporotic fractures. Plyometrics is one of the most effective types of exercises for stimulating bone growth. The aim of the study was first to evaluate the effectiveness of plyometrics benefits on physiological parameters of osteoporosis among premenopausal women. Second to find out the association between the physiological parameters of osteoporosis among premenopausal women with selected demographic variables. The research approach was a Quantitative approach. Design adapted for the study was a true Experimental design with one control group and one experimental group. Data collected from 40 self help group women who were the members of kanchi sangamam from a selected area at Chennai. Sample were collected by using simple random technique. Based on the inclusion criteria and availability of pre-menopausal women, they were allocated into the control group (n=20) and experimental group (n=20). Plyometrics was given to the experimental group for 12 weeks. The control group did not receive an intervention. It was analyzed by descriptive and inferential statistics. The study determined there is significant changes in physiological parameters of osteoporosis among the experimental group(p<0.001) as compared to the control group.