Phytochemical screening and evaluation of hepatoprotective activity of Mimusops elengi linn., bark

Abstract

Liver diseases are one among the deadly diseases in the world today. Since modern medicines are less effective in treating the liver diseases and it is the plant preparations which are most commonly and effectively used for the treatment of hepatic diseases, there is a need to develop some novel, potent plant preparations for treating the same. With this objective our present study includes phytochemical screening and evaluation of In-vivo hepato- protective activity of Mimusops elengi L bark. Here the powdered bark was subjected to successive Soxhlet extraction using different solvents of increasing polarity. The successive methanol and aqueous extracts were subjected for In-vivo hepatoprotective evaluation. The methanolic extract was found more effective. So it was further subjected for preliminary phytochemical and chromatographic examination. Attempt was made to isolate the compounds using isocratic elution technique. The isolated compounds was characterized by UV, FT-IR, ¹H-NMR,¹³C- NMR and mass spectroscopy.