Effects of Tagetes erecta gel on experimentally induced oral ulcer model in rats

Abstract

Tagetes erecta (African marigold) has various medicinal values. The present study has been undertaken to evaluate the effects of extracts of the fresh leaves and flowers of Tagetes erecta on oral ulcer models in wistar albino rats. The anti-ulcer activity of the extracts of Tagetes erecta (2.5% and 5%) was compared among leaf and flower extract and with the standard drug, Triamcinolone. Phytochemical screening of plant extract, extract action on oral ulcer and histopathology analysis were carried out. Tagetes erecta leaf and flower extracts have showed the presence of alkaloids, flavonoids, and carotenoids. Results has that Tagetes erecta leaf extract showed significant oral ulcer protective activity (83.6%) compared with the standard drug Triamcinolone. In the present work it can be concluded that the hydro alcoholic leaf and flower extracts of Tagetes erecta gel have better potential against oral ulcer which supports the traditional claims in folklore medicine.