Recent Review on Role of Resveratrol in Diabetes and its Complication

Abstract

Resveratrol, a non-flavanoid, is a trans-stilbene derivative and is a compound of great interest because of its wide pharmacological actions in disease such as cancer, diabetes and its complications, cardiac diseases etc. Resveratrol has been working effectively by acting as an antioxidant and interfere in the generation of free radicals, which in turn is the main cause of various diseases. Resveratrol has shown very effective in Diabetes and its complications such as Diabetic Retinopathy, Coronary Artery Disease, Diabetic cardiomyopathy, vascular dysfunction, Chronic Renal Failure and others. Though the main challenge comes in formulating Resveratrol as it has low solubility, low stability and less bioavailability. This review focuses on antioxidants being an essential class of compounds in the treatment of diabetes. Role of various antioxidants being studied along with showcasing their combined effect with resveratrol and also the mechanism of resveratrol in diabetes and its complications. Lastly, it also highlights various formulations of resveratrol which have shown improvement in solubility, stability and bioavailability. Thus Resveratrol is identified as an essential compound in the treatment of diabetes and its complications.