Cardioprotective Effect of Ethanolic Flower Extract of ClitoriaTernatea on Doxorubicin Induced Cardiotoxicity in Rats

Abstract

In this study, Doxorubicin is used as an effectual induction of cardiotoxicity and heart malfunction in the taken experimental rats which is an anthracycline chemotherapeutic mediator used to the treat of a wide variety of malignancies. To examine the shielding property of ethanolic flower extract of clitoraternatea  (EECT) scheduled doxorubicin(DOX) persuaded cardiotoxicity via albino wistar rats, through inspect the enzymatic,non-enzymatic antioxidant position, serum enzyme and Histopathology tissue. Experimental rats been provoked cardiotoxicity by means of a generous single dose of doxorubicin (15mg /body weight ) and treated orally through an ethanolic extract of clitoraternatea (EECT) for 14 days (100 mg/kg bw, 200 mg/kg bw and 300mg/kg bw,n=5). On 15 days, the rats are sacrificed by treated through Ketamine –Xylazine, Biochemical as well as histological remarks of the heart tissues had carry out. Management through EECT of 200mg/kg and 300mg/kg considerably reduced the levels of cardiac marker enzymes(p<0.05) and as well minimize the decrease of weight of the heart of DOX treated group. In heart tissue superoxide dismutase, glutathione and catalase heights be significantly greater than before and lipid oxide peroxide (LPO) significantly decreased in the extract (200 &300 mg /kg bw).