Biochemical and Hormonal Profile of Letrozole Induced Polycystic Ovarian Syndrome in Wistars Albino Rats treated with Cynodon dactylon

Abstract

The polycystic ovarian syndrome is associated with increases in androgen, hyperinsulinemia, secretion of a high level of luteinizing hormone, weight gain, anovulation, cyst formation, etc. Metformin is the drug used for treating PCOS with like nausea, vomiting, etc. in order to prevent the side effect and to find a better cure, and then metformin the present drug was selected Cynodon. dactylon  is commonly called as Arugampul, which is used for diabetes, antioxidant, anti-hyperlipidemic, etc. The animals were selected based upon the weight (125-150 gm) an oestrus cycle. 36 Wistars albino rat was taken and divided into six groups with each group six animals. Control group, Induced (PCOS) group, Referral (Metformin) group, Treatment group (C.dactylon) 500mg/kg, 1,000 mg/kg, 1,500 mg/kg. The animals were induced for PCOS first 21 days by giving Letrozole excluding the control group and examined for PCOS by vaginal smear. In the second 21 days, the animal was treated with the drug and Metformin, leaving the PCOS induced group. There was a significant change with control and PCOS group, PCOS and drug & Metformin group. We were able to observe very high significant changes in lipid profile and also significant changes in hormonal and glucose profiles of C. dactylon  group compared metformin group. The present study shows C. dactylon treats PCOS better than Metformin and bring backs the animals for normal condition.