ABCG2 Polymorphism in Hyperuricemia associated Type 2 Diabetes and Hypertension Patients

Abstract

Hyperuricemia is one of those syndromes that is highly inherited similar to obesity and body weight. There are many ongoing types of research in connection to the genetic inheritance of hyperuricemia. Existing studies have found out that, abnormal production of SNP rs2231142 of ABCG2gene, that belongs to the ATP-Binding cassette family, is responsible for the increased uric acid levels. Studies have proved that genetic polymorphism on the Q141K and V12M variants of the ABCG2 gene is responsible for the abnormal uric acid levels. Hence, people carrying these alleles are more likely to develop hyperuricemia. However, the extent of association of ABCG2 and hyperuricemia was found to vary with ethnicity. So, we have selected the same SNP rs 2231142 of the variants Q141K, in order to establish the theory of hyperuricemia variation with ethnicity. Here we want to study the significance of ABCG2 polymorphism in hyperuricemia patients suffering from type 2 diabetes and hypertension in the district of Srikakulam in South India. The aim of the present study was to find an association of novel ABCG2 gene with hyperuricemia in Srikakulam population attending GEMS&H, who are diagnosed as hyperuricemic and are suffering from type 2 diabetes and hypertension for more than 5 years. The study population is selected based on the disease conditions such as hypertension, hyperlipidemia, and type 2 diabetes. A total of 100 subjects were involved. Genomic DNA is extracted from the whole blood and gene polymorphism was identified by PCR and RFLP. Hyperuricemia was positively associated with age, obesity and alcoholism. The SNP locus rs2231142 of the ABCG2 gene was found to be associated with hyperuricemia and found significant in obese alcoholic men who are suffering from type 2 diabetes and hypertension.