Synthesize and Characterization of New Polydimethylsiloxane Derivatives with Evaluation of Biological Activities

Abstract

New polymers of silicone derivatives were prepared. The polymers were characterized by IR, NMR spectrophotometry. The biological activity against Streptococcus, E-Coli, Pseudomonas, Staphylococcus, Klebsiella were studied. The new polymers have shown more activity against Pseudomonas, Staphylococcus aureus, Klebsiella. The wound dressing studied on New Zealand White Rabbits (5 groups) each group contained 6 rabbits (3 male and 3 female), each animal had made 2 wounds,one for control (povidone-iodine, silicone gel) and other for our compounds, all products showed good activity on open wounds more than drugs in market. Benzaldehyde is consists of benzene bearing a single formyl substituent; the simplest aromatic aldehyde and parent of the class of benzaldehydes. It has a role as a flavoring agent, a fragrance, an odorant receptor agonist. Polyvinylpyrrolidone has disinfectant properties, so we used it in our compound to become more potent.