Antidiabetic and antihyperlipidemic activity of Premna latifolia extract in streptozotocin-induced diabetic rats

Abstract

In this research work, we studied the effect of alcoholic extract of plant Premna latifolia (leaves) on the enzymes associated with metabolism of carbohydrate and lipid in the rats models with induced diabetes employing Streptozotocin. Administration of alcoholic extract of Premna latifolia was made to these diabetic rats at doses of 100 mg/kg and 200 mg/kg once a day for three weeks. Various changes specifically, glucose levels in blood, insulin, total cholesterol content in serum, triglycerides, High Density Lipoprotein levels, Low Density Lipoprotein levels along with variations in the body weight were measured. Numerous enzymes involved in the metabolism of carbohydrate and lipids viz. amylase, lipase, Aldolase, Glucose-6-phosphatase, Phosphogluco isomerase, Fructose- 1,6-diphosphatase, and Glucose-6-phosphate dehydrogenase have been evaluated. Further, the histopatholgical changes in pancreas have been studied and reported. This study substantiates that the alcoholic extract of Premna latifolia normalizes the blood glucose, insulin, lipid profile by regulating pancreatic and hepatic enzyme levels in diabetic rats. Alcoholic extract of Premna latifolia lowers glucose and lipid levels in the blood of diabetic rats.