Design and in vitro evaluation of mucoadhesive drug delivery of Nateglinide

Abstract

The aim of the present work was to design and evaluate mucoadhesive drug delivery system of nateglinide. The novel mucoadhesive tablets were involves the three preparation process may include adhesive cups, core material and tablets. FTIR and DSC analysis is performed for drug-polymer interaction studies there is no interaction between drug and polymers. Nateglinide core material in adhesive cups are influenced by the many number of physical and chemical parameters. Adhesive cup formulations MAC2, MAC4, MAC8, MAC9 and MAC10 that showed superior qualities in the adhesive strengths and hence they were selected for further studies. Drug release from various mucoadhesive tablets was slow and prolong the release rate up to 12 hr and depended on composition, polymers ratio with drug.