T786C Polymorphisms of Endothelial Nitric Oxide Synthase 3 (eNOS3) in basket ball players

Abstract

Genetic factor plays an important role in athletes performance. This study was amid to explain individual variability in eNOS3 – T786C polymorphism that acts a vital role athletes performance. The endothelial nitric oxide synthase three gene variant has been studied. The T786C polymorphism of eNOs3 gene studied in power and endurance sport. The genotypic and allelic frequencies of the eNOS3 T786c polymorphism in basketball players compare with control group. DNA extracts from 35 man player basketball and 40 healthy men as a control. The T786C polymorphism was determined genotype by polymerase chain reaction-restriction fragment length polymorphism (PCR- RFLP). The frequency of the T allele was significant for basketball player compared to the control group (60% vs 40.5%, P= 0.334). While genotypes disruption there is no statically significant among basketball player (40% TT, 40% TC, 20% CC) compared with control (30% TT, 25% TC, 18% CC), (p=0.365, 0.167, 0.069 respectively). It was concluded that T allele has a significant relationship with basketball players, and it has a beneficial effect on performance parameters, but it needed further study.