Development and characterization of stomach specific mucoadhesive drug delivery system of Baclofen

Abstract

The aim of the present investigation was to improve the bioavailability of baclofen by increasing the residence time of the drug by preparing gastroretentive mucoadhesive sustained release matrix tablet. Tablets were prepared by direct compression technique and evaluated for hardness, weight variation, thickness, content uniformity, swelling index, mucoadhesive force, mucoadhesive retention period and in vitro drug release. Formulation B8, containing sodium alginate, HPMC K100M, Carbopol 974P and ethyl cellulose was found to control the release of Baclofen for more than 12 hrs with cumulative percentage of drug release 70.79 %. The mucoadhesive studies reveraled that batch B8 and B1 found to be good mucoadhesive strength and mucoadhesive retention period. For all formulations, kinetics of drug release from tablet followed by Matrix and Korsemeyer Peppas model, which states that the release of might follow Non-Fickian diffusion as predominant mechanism of drug release. Mucoadhesive system found to be promising approach for gastro retentive controlled delivery of Baclofen which is capable of sustaining release for 12 hours. The swelling and bioadhesion ability were found to be dependent on the composition of the polymer in the tablet.