Protective effects of dehydroepiandrosterone (DHEA) against Carbimazol-induced toxicity in male mice

Abstract

The present study conducted to evaluate the protective role of DHEA against the some side effects caused by carbimazole in male mice. Eighteen male mice were divided into three groups, the first group drenched distillated water as control, while second group gavaged with carbimazole and third group gavaged with carbimazole in combination with DHEA, all treatments were extended for thirty days. The results revealed that the mice treated with carbimazole caused significant decrease in serum T4 and T3 concentration, but TSH was significantly increased. An increase in serum values of AST, ALT, TG, TC, VLDL, LDL cholesterol, creatinin and Urea were also recorded. Combined DHEA with carbimazole significantly return these biochemical criteria to their values in control group. In spite of non-ameliorative effect of DHEA on thyroid hormones, the results refer to that DHEA ameliorates the lipid profile, hepatotoxicity and renal toxicity induced by Carbimazole in male mice.