Development and Evaluation of novel maltodextrin proniosomes for oral delivery of abacavir Sulphate

Abstract

The aim of the present work was to investigate feasibility of proniosomes in the encapsulation of hydrophilic anti-retroviral drug abacavir sulphate. This was performed and optimized by slurry method using different surfactants, cholesterol and dicetyl phosphate. Blank formulations comprising all the excipients were prepared and subsequently drug loaded formulations also prepared. The formulations were evaluated for vesicle formation, vesicle size, size distribution, zeta potential, encapsulation efficiency, drug content, in vitro drug release, release kinetics and micromeritic properties. The optimized formulation was evaluated for scanning electron microscopy, fourier transform infrared (FTIR) spectroscopy, osmotic shock studies and stability study. The tween series formulations non significantly (P=0.12>0.05) enhanced the encapsulation of abacavir sulphate compared with the formulations with span series surfactants. Among all the proniosome formulations, CDPF7 containing tween 60 was selected as an optimized formulation due to high encapsulation efficiency of 85.02 ±1.560%, prolonged drug release of 94.46 (±1.396)% after 24 hours and better stability.