Effect of nanotization on therapeutic activities of biomolecules: Synthesis and Characterization

Kumara H.K; Parikshith Gowda K.R; Suyoga Vardhan D.M; Pavan Kumar H; Channe Gowda D

Kumara H.K ⁽¹⁾ , Parikshith Gowda K.R ⁽²⁾ , Suyoga Vardhan D.M ⁽³⁾ , Pavan Kumar H ⁽⁴⁾ , Channe Gowda D ⁽⁵⁾

(1) Department of Studies in Chemistry, University of Mysore, Manasa gangotri, Mysuru - 570 006, Karnataka, India, India ,

(2) Department of Studies in Chemistry, University of Mysore, Manasa gangotri, Mysuru - 570 006, Karnataka, India, India ,

(3) Department of Studies in Chemistry, University of Mysore, Manasa gangotri, Mysuru - 570 006, Karnataka, India, India ,

(4) Department of Studies in Chemistry, University of Mysore, Manasa gangotri, Mysuru - 570 006, Karnataka, India, India ,

(5) Department of Studies in Chemistry, University of Mysore, Manasa gangotri, Mysuru - 570 006, Karnataka, India, India

Issue
Vol. 8 No. 2 (2017): Volume 8 Issue 2

Keywords:

Nanoparticles, Dialysis, Quinazolinone, Dipeptides, Bioactivity

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Abstract

The bioactive organic nanoparticles were synthesized by precipitation-dialysis method from their corresponding bulk forms. The morphology and average particle size of the synthesized nanoparticles were characterized by scanning electron microscope (SEM) and dynamic light scattering (DLS) techniques. The nanotization decreases the particles size by 2-20 times with a narrow range of distribution and also considerable change in the shape. Further, the nanoparticles (1-10) and their bulk forms (1B-10B) were evaluated for in vitro antioxidant, anti- inflammatory and antimicrobial activities. The biological assay data revealed that new organic nanoparticles showed enhanced biological activity compared to their corresponding bulk forms. This may be due to increase in the surface area and decrease in the particles size after nanotization.