Antiarthritic activity of leaf extracts of Pamburus missionis Swingle

Abstract

The current work was carried to examine anti -arthritic activity of leaves of Pamburus missionis in male albino rats by using CFA induced arthritis model . Acute toxicity study was carried out according to OECD 425 guidelines. The study was carried out for 28 days where the animals were treated with 200 and 400 mg/kg ethanolic extract of leaves of Pamburus missionis after inducing arthritis in rats by Freund’s adjuvant. Further on 28th day the rats were subjected for the evaluation of inflammatory parameters like paw volume, paw thickness and Knee diameter. Blood was retracted from each animal of retro-orbital venous plexus of rats and it is collected into vial containing EDTA which is subjected for haematological parameters viz., RBC count, WBC count, Hb, ESR and RA factor. Both inflammatory and antiarthritic activity parameters were made endorsed by radiographic images. Treatment with ethanolic extract of Pamburus missionis showed significant (P<0.05) report at a dose of 400mg/kg body weight showed most potent and significant activity, evidenced by analyzing the inflammatory parameters, haematological parameters and radiographical analysis. Hence the current study revealed that ethanolic extract of Pamburus missionis (Swing.) possesses antiarthritic activity, due to the medial of phytoconstituents present in the plant extracts.