Formulation and evaluation of mouth dissolving tablets of rosuvastatin by taste masking with eudragit epo

Abstract

Acceptability of any dosage form mainly depends on its taste i.e., mouth feel. Drug molecules interact with taste receptor on the tongue to give bitter, sweet or salty taste sensation, when they dissolve in saliva. This sensation of the taste is the result of signal transduction from the receptor organs for taste. In the present study, attempts were made to conceal the bitter taste of Rosuvastatin by taste masking agent employing solid dispersion technique. By employing solvent evaporation method and Eudragit EPO as carrier polymer different ratios of solid dispersions were prepared. The better ratio in which the bitter taste of drug was completely concealed was selected. The finalized ratio was compressed into mouth dissolving tablet dosage forms by using super disintegrates. The prepared solid dispersions were analysed for drug content and drug release characteristics, instrumentally by DSC, XRD, FTIR studies. The prepared powder blend of tablets was analysed for flow properties and the tablets were analysed for disintegration, dissolution and other quality control tests of tablets.