Preparation, Characterization and Stability Study of Oral Reconstitutable Suspension of Amoxicillin and Potassium Clavulanate

Pranit P Atpadikar; Amol S Sherikar; Mahanthesh M C; Disouza J I

doi:10.26452/ijrps.v13i2.452

Pranit P Atpadikar ⁽¹⁾ , Amol S Sherikar ⁽²⁾ , Mahanthesh M C ⁽³⁾ , Disouza J I ⁽⁴⁾

(1) Department of Quality Assurance, Tatyasaheb Kore College of Pharmacy, Warananagar – 416 113, Maharashtra, India, India ,

(2) Department of Quality Assurance, Tatyasaheb Kore College of Pharmacy, Warananagar – 416 113, Maharashtra, India, India ,

(3) Department of Pharmacognosy, Tatyasaheb Kore College of Pharmacy, Warananagar – 416 113, Maharashtra, India, India ,

(4) Department of Quality Assurance, Tatyasaheb Kore College of Pharmacy, Warananagar – 416 113, Maharashtra, India, India

https://doi.org/10.26452/ijrps.v13i2.452

Issue
Vol. 13 No. 2 (2022): Volume 13 Issue 2

Keywords:

Reconstitutable, Micromeritic, Carr’s Index, HPLC Assay, Accelerated Stability

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Abstract

To overcome the problem of bitter taste, degradation, and sedimentation, reconstitutable suspension of Amoxicillin and Potassium Clavulanate was prepared. The suspension was prepared by using two different formulations. The suspensions were characterized for micromeritic studies such as bulk density, tap density, Car’s index, angle of repose, pH, and viscosity. The HPLC assay was performed for the quantitative determination of Amoxicillin and Clavulanate potassium from suspension. The accelerated stability study was carried out to predict the stability profile of a drug product. Formulated reconstitutable suspension of Amoxicillin and Potassium Clavulanate has IPQC properties. From the results, it is concluded that reconstitutable suspension was successfully prepared and evaluated.

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Authors

Pranit P Atpadikar

Department of Quality Assurance, Tatyasaheb Kore College of Pharmacy, Warananagar – 416 113, Maharashtra, India

Amol S Sherikar

Department of Quality Assurance, Tatyasaheb Kore College of Pharmacy, Warananagar – 416 113, Maharashtra, India

assherikar.tkcp@gmail.com (Primary Contact)

Mahanthesh M C

Department of Pharmacognosy, Tatyasaheb Kore College of Pharmacy, Warananagar – 416 113, Maharashtra, India

Disouza J I

Department of Quality Assurance, Tatyasaheb Kore College of Pharmacy, Warananagar – 416 113, Maharashtra, India

Pranit P Atpadikar, Amol S Sherikar, Mahanthesh M C, & Disouza J I. (2022). Preparation, Characterization and Stability Study of Oral Reconstitutable Suspension of Amoxicillin and Potassium Clavulanate. International Journal of Research in Pharmaceutical Sciences, 13(2), 231–239. https://doi.org/10.26452/ijrps.v13i2.452