Evaluation the role of Trimetazidine in managing impaired fertility in rats treated with alloxan-induced hyperglycemia

Abstract

It has been shown that the chronic metabolic derangement accompanying long-standing hyperglycemia, both in experimental animals and man, may alter fertility in males. Recent reports have investigated the role of Trimetazidine in improving fertility parameters; however, the results are still controversial. This study was aimed to evaluate the role of Trimetazidine concerning fertility parameters in experimentally induced hyperglycemia in rats. Three groups of rats have subjected to alloxan induced hyperglycemia, placebo treatment (control group), and alloxan and TMZ treatment (study group). Each group included ten animals. Sperm parameters, hormonal levels, markers of oxidative stress and Histophotometry were done according to previously published literature. Sperm parameters in the form of sperm count, normal morphology, motility and number of dead sperms were significantly altered following alloxan induced hyperglycemia (P< 0.001). The administration of TMZ showed significant improvement in sperm parameters (P<0.001) in addition to significant improvement in markers of oxidative stress, GSH, SOD, MDA and NO (P< 0.001), and in hormonal levels, testosterone and FSH (P< 0.001). TMZ is useful in optimizing fertility parameters in experimental rats following alloxan induced hyperglycemia through antioxidant mechanisms and improved hormonal profile.