Study of physicochemical properties of TTDMM dendrimer (Trimesyol- 1,3,5-tridimethyl malonate) with cationic and anionic surfactants to make drug delivery system more effective

Abstract

The physicochemical properties (PCPs) like density, surface tension, viscosity, activation energy, friccohesity and molecular radii of 1st generation Trimesyol-1,3,5-trimethyl malonate (TTDMM) dendrimer with sodium dodecyl sulfate (SDS) and dodecyl trimethyl ammonium bromide (DTAB) surfactants in DMSO solvent were studied at 298.15 K and 0.1 MPa. For physicochemical properties and molecular radii of Dendrimer/Surfactant-Solvent systems 0.2, 0.4, 0.6 and 0.8 mM/L were prepared for TTDMM, SDS, DTAB in DMSO. For dendrimer-surfactant-solvent 0.2, 0.4, 0.6 and 0.8 mM/L of SDS and DTAB were prepared and mixed in 0.4mM/L solution of TTDMM in DMSO. Densities were measured by using Anton Paar Density and Sound velocity meter DSA 5000 M with ±10-3 kg m-3 accuracy. Viscous flow time for viscosity and pendant drop numbers for surface tension were measured with Borosil-Mansingh Survis meter. The data were regressed for limiting densities, surface tension, viscosities, friccohesity, activation energies and particle size to depict SDS-TTDMM and DTAB-TTDMM binding activities. The studies revealed that the interaction of TTDMM with SDS and DTAB surfactants lead to aggregation process with hydrophilic and hydrophobic domains where SDS showed stronger interactions than DTAB. This may lead to their applications in the drug delivery systems based on the structural properties of the drug molecules for binding and releasing process. Hence, these studies may open up new windows in the field of pharmaceutical sciences.