Comparing efficacy and safety of sodium valproate with propranolol in paediatric migraine prophylaxis
Article Sidebar
-
Headaches, Antiepileptic, Antidepressant, Beta-blockers
Abstract
Migraine is a common disorder of the paediatric age group. Propranolol has been used in prophylaxis for migraine. The use of Sodium valproate in the prophylaxis of migraine is not known. It is postulated that it increases the level of GABA in the brain that will decrease events related to migraine in the cortex. All parents of the patient were advised to keep diaries for noting time, date, severity and duration of headache during the study period, which was for a period of 6 wks. The decreased frequency of headache more than in Group A was 68% and propranolol group was 68.89%. In group A(sodium valproate), patients showed a reduction in headache duration and 52% in Group B. 20% of them headache free in Group A and 18% in Group B. Decrease in the severity of headache in Group A was 52% while 50% in Group B. The mean headache frequency before and after treatment was reduced from 8 to 2.5 attacks per month in group A and from 8.2 to 2.6 in group B. The t-value is 11 for group A. Sodium valproate is more effective and safer in migraine prophylaxis as compared with propranolol.
Full text article
References
Afshari, D., Rafizadeh, S., Rezaei, M. 2012. A Comparative Study of the Effects of Low-Dose Topiramate Versus Sodium Valproate in Migraine Prophylaxis. International Journal of Neuroscience, 122(2):60– 68.
Ashrafia, M. R., Shabaniana, R. 2005. Sodium Valproate versus Propranolol in paediatric migraine prophylaxis. European Journal of Paediatric Neurology, 9(5):333–338.
Bidabadi, E., Mashouf, M. 2010. A randomized trial of propranolol versus sodium valproate for the prophylaxis of migraine in pediatric patients. Randomized Controlled Trial Paediatr Drugs, 12(4):269–275.
Bostani, A., Rajabi, A., Moradian, N., Razazian, N., Rezaei, M. 2013. The effects of cinnarizine versus sodium valproate in migraine prophylaxis. International Journal of Neuroscience, 123(7):487–493.
Carroll, J. D., Reidy, M., Savundra, P. A., Cleave, N., McAinsh, J. 1990. Long-Acting Propranolol in the Prophylaxis of Migraine: A Comparative Study of Two Doses. Cephalalgia, 10(2):101–105.
Dakhale, G. N., Sharma, V. S. 2019. Low-dose sodium valproate versus low-dose propranolol in the prophylaxis of common migraine headache: A randomized, prospective, parallel, open-label study. 51(4):255–262.
Damen, L. 2005. Symptomatic Treatment of Migraine in Children: A Systematic Review of Medication Trials. Pediatrics, 116(2):e295–e302.
Diener, H. C., Matias-Guiu, J., Hartung, E., Pfaffenrath, V., Ludin, H. P., Nappi, G., de Beukelaar and, F. 2002. Efficacy and Tolerability in Migraine Prophylaxis of Flunarizine in Reduced Doses: A Comparison with Propranolol 160 Mg Daily. Cephalalgia, 22(3):209–221.
Dooley, J. B. 2009. The evaluation and management of paediatric headaches. Paediatr Child Health, 14(1):24–30.
Jensen, R., Brinck, T., Olesen, J. 1994. Sodium valproate has a prophylactic effect in migraine without aura: A triple-blind, placebo-controlled crossover study. Neurology, 44(4):647–651.
Lewis, D. W. 2004. Toward the definition of childhood migraine. Curr Opin Pediatrics, 16(6):628– 636.
Ramadan, N. M. 2004. Prophylactic migraine therapy: Mechanisms and evidence. Current Pain and Headache Reports, 8(2):91–95.
Rompel, H., Bauermeister, P. W. 1970. Aetiology of migraine and prevention with Carbamazepine (Tegretol): a result of a double-blind, cross-over study. S Afr Med J, 44(4):75–80.
Sadeghian, H., Motiei-Langroudi, R. 2015. Comparison of Levetiracetam and sodium Valproate in migraine prophylaxis: A randomized placebo controlled study. Annals of Indian Academy of Neurology, 18(1):45–48.
Stovner, L. J., Linde, M., Gravdahl, G. B., Tronvik, E., Aamodt, A. H., Sand, T., Hagen, K. 2014. A comparative study of candesartan versus propranolol for migraine prophylaxis: A randomised, triple-blind, placebo-controlled, double cross-over study. Cephalalgia, 34(7):523–532.
Wasiewski, W. W. 2001. Preventive Therapy in Pediatric Migraine. Journal of Child Neurology, 16(2):71–78.
Wöber-Bingöl, Ç. 2013. Epidemiology of Migraine and Headache in Children and Adolescents. Current Pain and Headache Reports, 17(6):341.
Yurekli, V. A., Akhan, G., Kutluhan, S. 2008. The effect of sodium valproate on chronic daily headache and its subgroups. The Journal of Headache and Pain, 9(1):37–41.
Authors
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.