Lipid peroxidation and superoxide dismutase levels variation in hypothyroidism patients

Abstract

The study aims to find the antioxidant status in hypothyroidism. Hypothyroidism is otherwise known as an underactive thyroid. It takes place when the thyroid gland does not produce enough thyroid hormone for the body need. 40 subjects were divided into two groups of the normal healthy individual (20 in numbers) as Group I and hypothyroidism patients (20 in numbers) as Group II from the dental outpatient department of Saveetha Dental College and Hospitals. Blood samples were collected from the participants, and it was distributed in a plain collection tube and centrifuged in 2500 rpm for 10 minutes. The Serum was separated and analysed for Melanaldehyde and Superoxide dismutase by TBARS method and Pyrogallol Autoxidation method using ERBA CHEM 5 plus analyser. There is a significant increase in (MDA) lipid peroxidation (p<0.005) as well as there is a significant decrease in (SOD) superoxide dismutase (p<0.005) in Hypothyroidism patients. Our study revealed that the women with PCOS have an imbalance in their antioxidant status. Increased oxidative stress and decreased antioxidant capacity may contribute to the increased risk of CVD in women with Hypothyroidism. Further research on oxidative stress in hypothyroidism is needed.