Evaluation of carbamylated darbepoetin acute toxicity

Pavel D Kolesnichenko; Oleg S Gudyrev; Maksim A Zhuchenko; Nina I Zhernakova; Alexandr V Faitelson; Marina A Pershina; Vladislav O Soldatov

Pavel D Kolesnichenko ⁽¹⁾ , Oleg S Gudyrev ⁽²⁾ , Maksim A Zhuchenko ⁽³⁾ , Nina I Zhernakova ⁽⁴⁾ , Alexandr V Faitelson ⁽⁵⁾ , Marina A Pershina ⁽⁶⁾ , Vladislav O Soldatov ⁽⁷⁾

(1) Department of Pharmacology, Belgorod State University, Russia, 308015, Belgorod, Pobedy street, 85, Russia, Russian Federation ,

(2) Department of Pharmacology, Belgorod State University, Russia, 308015, Belgorod, Pobedy street, 85, Russia, Russian Federation ,

(3) Department of Pharmacology, Belgorod State University, Russia, 308015, Belgorod, Pobedy street, 85, Russia, Russian Federation ,

(4) Department of Pharmacology, Belgorod State University, Russia, 308015, Belgorod, Pobedy street, 85, Russia, Russian Federation ,

(5) Department of Pharmacology, Belgorod State University, Russia, 308015, Belgorod, Pobedy street, 85, Russia, Russian Federation ,

(6) Department of Pharmacology, Belgorod State University, Russia, 308015, Belgorod, Pobedy street, 85, Russia, Russian Federation ,

(7) Department of Pharmacology, Belgorod State University, Russia, 308015, Belgorod, Pobedy street, 85, Russia, Russian Federation

Issue
Vol. 9 No. 3 (2018): Volume 9 Issue 3

Keywords:

Erythropoietin, Carbamylated darbepoetin, Rats, Hypoxia, Acute toxicity

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Abstract

Carbamylated darbepoetin is a promising pharmacological agent with universal cytoprotective activity. To assess the acute toxicity, the drug was administered to white laboratory mice and white laboratory rats subcutaneously (from 1000 to 5000 μg / kg) and intravenously (500 to 2500 μg / kg). There was no lethality and no phenotypic changes (including from the red blood sprout) in both species of animals. The study showed that the drug carbamylated darbepoetin (Pharmapark, Russia) belongs to the IV class of low-toxic drugs.