Development of Osmotic Drug Delivery System to Control the Release Pattern of Drug Repaglinide

Abstract

The osmotic drug delivery system is a specific type of drug delivery system that regulates the medication release pattern using osmotic pressure. The components of this system include a drug core, a semipermeable membrane, and an osmotic agent. Water is transferred into the osmotic agent across the semipermeable membrane when the drug delivery system is placed in an aqueous environment. This causes the osmotic agent to expand and put pressure on the drug core. This pressure causes the medicine to be released under regulated conditions via a tiny opening in the semipermeable membrane. In comparison to conventional drug delivery methods, the development of osmotic drug delivery systems provides a number of benefits, including increased therapeutic effectiveness, less toxicity, and enhanced patient compliance. The semipermeable membrane's composition, the type and amount of the osmotic agents being employed, as well as the size and number of orifices, may all be changed to easily adjust the rate at which medications are released. In the present work, an osmotic drug delivery system of Repaglinide drug had been developed and characterized with various parameters. This drug delivery system showed potential results to improve drug delivery in the patients.