A review on the neuroprotective effect of Nelumbo nucifera seed pod

Abstract

Receptaculum Nelumbinis, the dried seed pod of Nelumbo nucifera, exhibited good efficacy for improving learning and memory abilities. Earlier, studies revealed that Receptaculum Nelumbinis can exert therapeutic effects in diverse disorders like heart failure, neoplasm via anti-oxidative, anti-inflammatory and anti-proliferative activities. In the central nervous system (CNS), Receptaculum Nelumbinis (RN) also has beneficial effects on various disorders, such as Alzheimer's disease (AD), depression, Parkinson's disease (PD), cerebral ischemia, epilepsy, and Huntington's disease (HD). RN also enhances memory and cognition ability of rodents in dissimilar pathological conditions, such as stress exposure, diabetes, aging and high-fat diet (HFD). The effect of noise stress on exploratory, locomotor, and anxiolytic activity in the open-field behavior (OFB) test and the effect of drug RN and active component quercetin, a flavonoid isolated from seedpod in overcoming these changes. Optimistically, getting a vibrant impression concerning the role of RN in the CNS, the present paper summarizes and discusses the pharmacological effects of RN as well as its possible mechanisms in CNS disorder prevention and or therapy.