Isolation and Insilico evaluation of artemisinin from ethanolic extract of Artemisia indica willd for antidiarrhoeal activity

Abstract

The present study investigates the Isolation and insilico evaluation of Artemisinin from ethanolic extract of Artemisia indica Willd for antidiarrhoeal activity is a medicinal plant which has been valued for centuries in ayurvedic medicine. Phyto-chemical screening of Artemisia indica plant extracts revealed the presence of various active constituents such as alkaloids, flavonoids, flavanones, Carbohydrates, steroids and terpenoids. Since terpenoids have remarkable anti-diarrhoeal activity, our present work aims at evaluating the anti -diarrhoeal activity of Artemisinin which is a sesquiterpenoid lactone isolated from Artemisia indica by thin layer chromatography and eval uated by docking studies. The results of our studies suggests that artemisinin showed more anti -diarrhoeal activity than the standard drug loperamide when binded with the µ opioid receptors. Therefore our results support the use of artemisinin in treating diarrhoea in animal studies. We hope it might become a good antidiarrhoeal drug in future.