Synthesis and evaluation of antioxidant activities of novel quinazolin derivatives

Walaa. S. El-serwy (1) , Neama. A. Mohamed (2) , Weam. S. El-serwy (3) , Emad. M. M. Kassem (4) , Khaled Mahmoud (5)
(1) Therapeutical Chemistry Department, National Research Centre, Dokki, Giza, Egypt, Egypt ,
(2) Therapeutical Chemistry Department, National Research Centre, Dokki, Giza, Egypt, Egypt ,
(3) Microbial and Natural Products Chemistry Department, National Research Centre, Dokki, Giza, Egypt, Egypt ,
(4) Therapeutical Chemistry Department, National Research Centre, Dokki, Giza, Egypt, Egypt ,
(5) Department of Pharmacognosy, National Research Centre, Giza 12622, Egypt, Egypt

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Vol. 6 No. 1 (2015): Volume 6 Issue 1
Keywords:
    Quinazolin, benzoxazin, cytotoxic activity
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Abstract

Different acid chlorides 2a-c are used as starting material of a number of 2-(substituted)-4H-3,1-benzoxazin-4-one derivatives 3a-c, Some of the newly synthesized analogues were chosen to evaluate their cytotoxic activity against human carcinoma cell lines (MCF7-HePG2–HCT116).

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Authors

Walaa. S. El-serwy
Therapeutical Chemistry Department, National Research Centre, Dokki, Giza, Egypt
walaasalah16@yahoo.com (Primary Contact)
Neama. A. Mohamed
Therapeutical Chemistry Department, National Research Centre, Dokki, Giza, Egypt
Weam. S. El-serwy
Microbial and Natural Products Chemistry Department, National Research Centre, Dokki, Giza, Egypt
Emad. M. M. Kassem
Therapeutical Chemistry Department, National Research Centre, Dokki, Giza, Egypt
Khaled Mahmoud
Department of Pharmacognosy, National Research Centre, Giza 12622, Egypt
Walaa. S. El-serwy, Neama. A. Mohamed, Weam. S. El-serwy, Emad. M. M. Kassem, & Khaled Mahmoud. (2015). Synthesis and evaluation of antioxidant activities of novel quinazolin derivatives. International Journal of Research in Pharmaceutical Sciences, 6(1), 62–74. Retrieved from https://ijrps.com/home/article/view/3906
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