Investigation on hypoglycemic, antioxidant and Hypolipidemic activity of ethanolic leaf extract of Cordia sebestena in streptozotocin-induced diabetic rats

Abstract

Herbal drugs are frequently considered to be less toxic and also free from side effects, than synthetic ones. Hence, the present study is an attempt to study antihyperglycemic property of Cordia sebestena against streptozotocin induced diabetes. The effect of alcoholic extract of Cordia sebestena on blood glucose and liver glycogen were studied in the diabetic rats. The study also assessed for the effect of plant extract for their effect on SOD, catalase, GSH and LPO in the homogenates of the pancreas. The results of the present study attests significant antidiabetic and antioxidant potential for the selected plants individually and also in combination as a prominent decrease in blood glucose and liver glycogen was observed in the rats treated with the extracts of the selected plants. Similarly, the levels of the protective antioxidant enzymes like SOD, catalase and GSH were increased along with decrease in the LPO levels. The present study provides a scientific evidence for antidiabetic and antioxidant potential of Cordia sebestena.