Review on substituted 1, 2, 4-triazoles as potent antifungal and antibacterial agents

Abstract

For the past two decades, modification of 1, 2, 4 triazole nucleus have made a tremendous significance in medicinal chemistry. 1, 2, 4 triazoles and their derivatives are found to have wide variety of pharmacological uses. From literature survey it is well known that triazole heterocycles exhibit manifold importance in the field of medicinal chemistry as a potent chemotherapeutic agent. Triazole is a synthetically versatile substrate used for the synthesis of a large variety of heterocyclic compounds, such as triazole fused with thiadiazole, oxadiazole and as a raw material for drug synthesis. Much work has been carried out on triazoles as potent anti fungal agents and many drugs with triazole nucleus having antifungal properties have come into the market (e.g. Fluconazole, Voriconazole, Itraconzole). This review represents the synthesized 1,2,4 triazole derivatives and their pharmacological profiles which may contribute in future to synthesize various analogs and to develop new pharmacologically less toxic medicines.