Synthesis and evaluation of dialkyl-4-substituted-2,6-dimethyl-1,4- dihydropyridine-3,5-dicarboxylate derivatives as anticonvulsive agents

Abstract

A series of symmetrical dialkyl-4-substituted-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate derivatives were prepared by the classical Hantzsch method. This method involved in the condensation of aromatic aldehyde, alky- lacetoacetate and ammonia in methanol. The structure of all the twelve synthesized 1,4-dihydropyridne derivatives was confirmed by the IR, H¹NMR, and MASS spectra. All the synthesized compounds were screened for the anticonvulsant activity by using Maximal electroshock (MES) and Pentylenetetrazole (PTZ) induced models. Compounds 3F and 3L exhibited significant anticonvulsant activity in MES and PTZ induced seizure in rats.