Comparison between the effect of metronidazole and some plant extracts on parasite Cryptosporidium parvium in vivo

Abstract

The current study included the test of the efficiency of water extract for pomegranate peel and water extract from pumpkin seeds in the treatment of parasite Cryptosporidium parivum within the body of the organism and compared its effectiveness with metronidazole in the treatment to eliminate the same parasite within the body of the organism, was relied on (50) mouse mosquito moss age (8-10 weeks) and weight (25-30 g), the mice were first examined as soon as they were obtained to confirm their safety and the absence of previous intestinal parasites, then they were injected with parasite bags that collapsed to cause the disease, and the mice remained under observation until they were confirmed to obtain the infection, the mice were treated the first group was given the dose 392.0 mg/1.0 ml/mouse of metronidazole, the second group with a dose of 657.14 mg/1.0 ml of water extracts for pomegranate solutions, the third group took 1000 mg/1.0ml /g of pumpkin extract from Pumpkin seeds, plus a positive control group of 2x10 cysts/2.0 ml of bag suspension and 1.0 ml of normal saline solution, the results showed to absence of cysts of parasites completely on the sixth day of the group that took metronidazole and on the seventh and eighth days of the two groups that used water extracts to peel the pomegranate and seeds of the pumpkin respectively for the positive control group, and that both the drug and the plant extracts achieved results of 100% in the treatment of infected mice and the elimination of parasite, and it seems clear that the highest efficiency was the share of the drug metronidazole followed by plant extracts.