Protective role of morin on some parameters related to oxidative stress and metabolic syndrome induced by acrylamide in male rats

Abstract

The objectives of this study were to explore the effects of morin on some physiological parameter including lipid profile, antioxidant status, and proinflammatory biomarkers in Acrylamide (ACR) treated rats. Forty adult male rats were selected randomly and equally allocated into four bunches that were G1, G2, G3 and G4, which were treated daily for 45 days with an oral manner as follows: G1: (control group received distilled water). G2: rats in this group were received (25 mg/kg/B. W) of morin. G3: rats of this group were received (1 mg/kg/B. W) of acrylamide in drinking water G4: rats in this group were received (25 mg/kg /B. W) of morin and Acrylamide (1 mg/kg /B. W). Fasting blood samples were collected by cardiac puncture technique at the end of the experiment. Blood was drawn by cardiac puncture technique for measuring the following parameters: total serum cholesterol (TC), (TAG) HDL-C, uric acid, Malondialdehyde (MDA) and glutathione (GSH). Sections of the liver were taken for histopathological study. The results of the current study revealed the beneficial effect of morin against deleterious effects of ACR illustrated by its antioxidant, anti-inflammatory effect. In conclusion, morin alleviates the determined effect of ACR correlated with their pro- oxidative and pro-inflammatory effects.