Effects of paroxetine on biochemical parameters and reproductive function in male rats
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Antidepressant, Paroxetine, Biochemical Parameters, Reproductive Function, Rat
Abstract
Selective serotonin reuptake inhibitors (SSRI) are a class of molecules used in treating depression, anxiety, and mood disorders. Paroxetine (PRT) is one of the most prescribed antidepressants, which has attracted great attention regarding its side effects in recent years. This study was planned to assess the adverse effects of paroxetine on the biochemical parameters and reproductive system. Fourteen male Wistar rats were randomly allocated into two groups (7 rats for each): control and treated with paroxetine at a dose of 5mg/kg.bw for two weeks. At the end of the experiment, blood was collected from the retro-orbital plexus for measuring the biochemical parameters, whereas the reproductive organs were removed for measuring semen quality and the histological investigations. Results showed that paroxetine induced significant changes in some biochemical parameters and alteration of semen quality, including sperm count, spermatids number and sperm viability, motility and abnormalities. The histopathological examinations of testis and epididymis revealed an alteration of spermatogenesis, cellular disorganization and vacuolization, enlargement of interstitial space, shrinkage and degenerative changes in the epithelium of seminiferous and epididymal tubules with few to nil numbers of spermatozoa in their lumen. In conclusion, paroxetine treatment caused changes in some biochemical parameters and sperm profiles as well as histopathologic effects of reproductive organs.
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References
Amodeo, L. R., Greenfield, V. Y., Humphrey, D. E., Varela, V., Pipkin, J. A., Eaton, S. E., Crawford, C. A. 2015. Effects of acute or repeated paroxetine and fluoxetine treatment on affective behaviour in male and female adolescent rats. Psychopharmacology (Berl), 232(19):3515–3528.
Atli, O., Baysal, M., Kilic, G. A., Kilic, V., Ucarcan, S., Karaduman, B., Ilgin, S. 2017. Sertraline induced reproductive toxicity in male rats: evaluation of possible underlying mechanisms. Asian Journal of Andrology, 19(6):672–679.
Bala, A., Nguyen, H. M. T., Hellstrom, W. J. G. 2018. Post-SSRI Sexual Dysfunction: A Literature Review. Sex Med Rev, 6(1):29–34.
Berger, M., Gray, J. A., Roth, B. L. 2009. The expanded biology of serotonin. Annu. Rev. Med, 60:355–366.
Blazak, W. F., Treinen, K. A., Juniewicz, P. E. 1993. 5-Application of testicular sperm headcounts in the assessment of male reproductive toxicity. Meth Toxicol, 3:86–94.
Brezina, P. R., Yunus, F. N., Zhao, Y. 2012. Effects of pharmaceutical medications on male fertility. J Reprod Infertil, 13(1):3–11.
Chigome, A. K., Matsangaise, M. M., Chukwu, B. O., Matlala, M., Sibanda, M., Meyer, J. C. 2017. Review of selective serotonin reuptake inhibitors. Pharmaceutical Journal, 84(6):52–59.
Cho, Y., Kim, E., Nyiramana, M. M., Shin, E., Jin, H., Ryu, J. H., Kang, K. R., Lee, G., Kim, H. J., Han, J., Kang, D. 2019. Paroxetine induces apoptosis of human breast cancer mcf-7 cells through ca2+- and p38 map kinase-dependent ROS generation. Cancers, 11(1):64.
El-Sheikh, S., Khairy, M., Fadil, H. A., Abo-Elmaaty, A. 2016. Ameliorative effect of Moringa Oleifera extracts on male fertility in paroxetine treated rats. Zagazig. Vet. J, 44(3):244–250.
Elmelegy, A. A. M., Kamal, S. M. 2013. Possible antioxidant and glutathione replenishing effects of paroxetine in liver homogenates of rats exposed to chronic restraint model. Journal of Pharmacology Research, 3(1):70–74.
Erdemir, F., Atilgan, D., Firat, F., Markoc, F., Parlaktas, B. S., Sogut, E. 2014. The effect of sertraline, paroxetine, fluoxetine and escitalopram on testicular tissue and oxidative stress parameters in rats. IntBraz J Urol, 4(1):100–108.
FDA 2017. Paroxetine tablets, USP 10 mg, 20 mg, 30 mg and 40 mg. Food and Drug Administration. APOTEX INC, Toronton, USA.
Ilgın, S., Aydoğan-Kılıç, G., Baysal, M., Kılıç, V., Ardıç, M., Uçarcan, S., Atlı, Ö. 2018. Toxic effects of trazodone on the male reproductive system via disrupting hypothalamic-pituitary-testicular axis and inducing testicular oxidative stress. Oxidative Medicine and Cellular Longevity, page 12.
Khushboo, Sharma, B. 2017. Antidepressants: mechanism of action, toxicity and possible amelioration. J Appl Biotechnol Bioeng, 3(5):437–448.
Liobet, J. M., Domingo, J. L., Colomina, M. T., Mayayo, E., Corbella, J. 1988. Subchronic oral toxicity of zinc in rats. Bull Environ Contam. Toxicol, 41(1):36–43.
Nash, J., Nutt, D. 2007. Antidepressants. Psychiatry, 6(7):289–294.
Rasmussen, J., Johnson, A., Stewart, B., Palmer, K. 1991. Paroxetine and fluoxetine on food intake in rats and effect of paroxetine on body weight in depressed patients. European Neuropsychopharmacology, 1(3):443–444.
Rim, K. T. 2017. Reproductive toxic chemicals at work and efforts to protect workers’ health: A literature review. Safety and Health at Work, 8(2):143–150.
Santana, Y., Montejo, A. L., Martín, J., Llorca, G., Bueno, G., Blázquez, J. L. J. L. 2019. Understanding the mechanism of antidepressant-related sexual dysfunction: inhibition of tyrosine hydroxylase in dopaminergic neurons after treatment with paroxetine but not with agomelatine in male rats. J. Clin. Med, 8(2):133.
Schenker, J. G., Meirow, D., Schenker, E. 1992. Stress and human reproduction. Eur J Obstet Gynecol Reprod Biol, 45(1):1–8.
Siepmann, T., Penzlin, A. I., Kepplingerj 2015. Selective serotonin reuptake inhibitors to improve outcome in acute ischemic stroke: possible mechanisms and clinical evidence. Brain Behav, 5(10):373.
Warner, M. E., Naranjo, J., Pollard, E. M., Weingarten, T. N., Warner, M. A., Sprung, J. 2017. Serotonergic medications, herbal supplements, and perioperative serotonin syndrome. Can J Anesth/J Can Anesth, 64(9):940–946.
Yakubu, M. T., Jomih, R. O. 2014. Aqueous extract of Carpolobia lutea root ameliorates paroxetine-induced anti-androgenic activity in male rats. Middle East Fertility Society Journal, 20(3):192–197.
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