Curative role of modified Arjunarishta on isoproterenol-induced myocardial infarction in rats

Abstract

World health organization estimates 16.7 million people globally die every year due to cardiovascular diseases. Huge attention is required towards CVD as it is causing quick health impact and lacking a better therapeutic solution. The present study was undertaken to evaluate the therapeutic effect of modified arjunarishta on isoproterenol-induced myocardial infarction in rats. In the experiment, animals were randomly divided into four groups (n = 6 rats per group). Group 1 served as normal control. Group 2 (Induced group) received Isoproterenol 85mg/kg body weight subcutaneously for the first two days (24 hrs interval) to induce myocardial infarction. Group 3 (Therapeutic model) received Isoproterenol as per group 2 followed by the administration of Modified Arjunarishta orally from 3^rd day to end of the experiment (16^th day). The effective dose of 400mg/kg body weight was fixed by dose fixation study. Group 4 (Arjunarishta model) received Isoproterenol as per group 2 followed by the administration of Standard Arjunarishta orally 2ml/kg body weight daily from 3^rd day to rest of the experiment period. At the end of the two-week experiment, Isoproterenol induced rats showed a significant increase in the levels of LDH, CPK, CK-MB, Troponin, SGOT, SGPT, Cholesterol, TGL, LDL and a significant decrease in the levels of HDL. The therapeutic activity estimated through biochemical parameters, cardiac markers and lipid profile.