The relationship between the level of albuminuria and severity of impairment in pulmonary function in type II diabetic patients

Abstract

Diabetes mellitus type II can lead to acute and chronic complications. The progression of many complications might be explained via modification of connective tissue and microangiopathy. The major microvascular structure in the body is the pulmonary alveolar- capillary network, which might be in- fluenced by diabetic microangiopathy. Diabetic nephropathy (DN) remains a major end-organ complication in diabetes. Complications of diabetes including pulmonary dysfunction and diabetic nephropathy have an analogous microangiopathic origin. There are numerous studies cover the relationship be- tween albuminuria and lung impairment in type I diabetic patients, but few studies about this relationship in type II diabetic patients, so current study aimed to assess the relationship between the levels of albuminuria and pulmonary function in diabetic patients type II. The design of the study is a cross- sectional study included 245 types II diabetic patients (119 male and 126 female), aged 41-80 years with mean ± SEM (57.43±0.54 years). Spirometry was done for all patients. Albumin/creatinine ratio and HbA1c were measured. There was a significant statistical negative relationship between ACR with FEV1 (% predicted) and FVC (% predicted). The progression of diabetic nephropathy to further advanced stages is associated with further changes in pulmonary function.