Compritol Solid Lipid Microparticles Loaded with Herbal Extracts for Acne Treatment

Abstract

Acne Vulgaris is an inflammation of sebaceous glands characterized by pustules and skin lesions. The usage of herbal cosmetics has been increased to many folds in personal care system and there is a great demand for the herbal cosmetics. The use of bioactive ingredients in cosmetics influence biological functions of skin and provide nutrients necessary for the healthy skin or hair. The present research work deals with Development and evalua- tion of solid lipid micro particles loaded with Grapes (Vitis venifera) seed and Marigold (Calendula officinalis) flower extract, and essential oils of Sea buckthorn (Hippophae rhamnoides )seeds for treatment of acne vulgaris. Compritol (5.0% wt/wt) SLM dispersions were prepared by oil in water emulsification method, using different sur- factant concentrations and Extract concentration. The SLM were characterized, in terms of surface morphology, particle size and stability. Solid lipid micro particle technology represents a promising new approach to lipophilic drug delivery. Herbal extract and oils were screened Phytochemical and TLC, HPLC were performed for Qualitative and Quantitative analysis of active constituents present. The formulation have been developed and evaluated.