Anticancer and antitubercular study of some 1,4-disubstituted [1,2,4]- triazolo[4,3-a] quinazolin-5(4H)-ones

Abstract

In the present study, a series of 1-substituted-4-(2-methoxyphenyl)-[1,2,4]-triazolo[4,3-a]quinazolin-5(4H)-ones were screened for their anticancer activity and anti tubercular activity. In vitro anticancer activity was determined against cancer cell lines HT-29, Hep-G2 and Hela using MTT assay and in vitro antitubercular activity was studied by agar dilution method using Mycobacterium tuberculosis strain H₃₇ Rv. Among the series of compounds, 1- chloromethyl-4-(2-methoxyphenyl)- [1,2,4]-triazolo[4,3-a]quinazolin-5(4H)-one showed moderate anti-cancer activity than other substituted quinazolin-5(4H)-ones. While, 1-ethyl-4-(2-methoxyphenyl)-[1,2,4]-triazolo [4,3-a] quinazolin-5(4H)-one and 4-(2-methoxyphenyl)-1-propyl-[1,2,4]-triazolo [4,3-a] quinazolin-5(4H)-one exhibited effective anti-tubercular activity with the MIC of 6.25 mg/mL.