Sustained release nanosuspension of acetaminophen- formulation and in-vitro evaluation

Abstract

The aim of this study was to prepare and characterize nanosuspensions of poorly water soluble drug (Acetaminophen) by modified solvent diffusion method using Eudragit L-100 polymer in order to sustain the release of Acetaminophen. Nanosuspension was subjected to various studies like particle size, pH, drug content, density, drug polymer interaction, in-vitro drug release and release kinetics. The spectral analysis revealed that there was no interaction and presence of drug. In-vitro studies showed sustained release of the drug for prolonged period.