In vitro antibacterial activities study of norfloxacin containing mucoadhesive suspensions

Abstract

To study the in vitro antibacterial properties of mucoadhesive suspensions containing Norfloxacin, three different formulations were prepared by using three polymers, such as Hydroxypropyl methylcellulose (HPMC) (S₁), Carba- pol934 (S₂) and Carbapol940 (S₃), along with some common ingredients (bases). For the antibacterial activities study of the suspensions agar well diffusion method was performed taking Staphylococcus aureus (ATCC 25923), Bacillus subtilis and Escherichia coli (ATCC 25922). Considering the overall antibacterial activity pattern of different suspensions, it may be concluded that S₁ was the most potent, and S₂ and S₃ were more or less equally effective formulations. Antibacterial properties of all the suspensions were either more or similar to those of pure drug in water (S₄). At least those formulations were not inferior to S₄, Marketed suspension containing Norfloxacin and Disc containing Norfloxacin. The negative controls of the study, i.e., the different bases and distilled water did not show any antibacterial activity.