Evaluation of anti-inflammatory and analgesic activity of poly herbal formulation (PHF) in albino rats

Abstract

The effect of poly herbal formulation consisting of Gum acacia suspension of Aegle marmelo leaves, Eugenia jambolana seeds and Bacopa monnieri leaves (1:1:1) respectively was investigated for analgesic and anti – inflammatory activity in various experimental models of pain and inflammation. Analgesic activity of PHF (50, 100 mg/kg, I.P) was studied in rats using, tail immersion method and hot plate method. Anti-inflammatory activity of PHF (100, 150mg/kg, I.P) was studied in rats using Histamine induced edema and egg white induced rat paw edema method. PHF (100 mg/kg I.P) significantly (p<0.01) increased latency to flick tail in tail immersion method and elevated the mean basal reaction time in hot plate method compared to control (2ml of1%Gum acaia suspension). PHF (150mg/kg) significantly (p<0.01) inhibited histamine and egg white induced rat paw edema, compared to standard drug Indomethacin (20mg/kgI.P).