Colon targeted drug delivery of propranolol hydro chloride by using different natural polymers

Abstract

Oral colon targeted drug delivery system have recently gained importance for delivering a variety of therapeutic agents for both local and systemic administration. The successful targeted delivery of drugs to the colon via the gastrointestinal tract requires the protection of a drug from degradation and its release in the stomach and small intestine and then ensures abrupt or controlled release in the proximal colon. This review represents the approaches for formulating colon targeted drug delivery dosage form of Propranolol HCl using polysaccharides like Guar gum, Ceratonia, Chitosan as polymer coating material. The various formulations having Chitosan (F1, F2, F3), Ceratonia (F4, F5, F6) and Guar gum (F7, F8, F9) were prepared using three respective concentrations (i.e 200mg, 250mg, 300mg) of each polymer. These were prepared by direct compression method and were evaluated analytically by in vitro method in rat caecal organ. The results from the study clearly shows that 200mg of Guar gum and 200mg of Chitosan in the form of a compression coat is a potential carrier for drug targeting to the colon because at that concentration of these polymer rapidly releases 86.6% (in case of guar gum) and 91.35% (in case of chitosan) of core drug in the colon. Evaluation parameters like Hardness (6.5-7.6kg/cm²), weight variation, drug uniform content (100±5%), friability (>1%) and in vitro dissolution profiles stated that F1 and F7 formulation having 200mg chitosan & 200mg of guar gum was confirmed as a ideal formulation for colon targeting.