Phytochemical evaluation and lipid lowering property of leaves of Vitex negundo linn. in hyper cholestremic rats | International Journal of Research in Pharmaceutical Sciences

Githa Elizabeth Mathew ⁽¹⁾ , Bijo Mathew ⁽²⁾ , Sajeeth C.I. ⁽³⁾

(1) Department of Pharmacology, Grace College of Pharmacy, Palakkad, Kerala, India, India ,

(2) Department of Pharmaceutical Chemistry, Grace College of Pharmacy, Palakkad, Kerala, India, India ,

(3) Department of Pharmaceutics, Grace College of Pharmacy, Palakkad, Kerala, India, India

Issue
Vol. 2 No. 1 (2011): Volume 2 Issue 1

Keywords:

Total cholesterol, triglycerides, HDL, LDL

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Abstract

The aim of the present study was to determine lipid lowering property of ethanol extract of Vitex negundo linn.The phytochemical studies performed as described by Wagner et al. Acute toxicity studies were performed initially in order to determine the safety of ethanol extract of Vitex negundo linn. (EEVN). In the present study the ethanol extract of Vitex negundo L. results a significant dose dependent reduction in Total Cholesterol and Low Density Lipoprotein level when compared with Cholesterol control group. Also all the treatment groups show a little bit increase in HDL level. Up on the triglycerides level the extracts posses a significant activity when compared to Lovastatin treated groups. The results demonstrate the effectiveness of the leaf of Vitex negundo L. as an anti-atherogenic agent preventing coronary artery diseases.

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Authors

Githa Elizabeth Mathew

Department of Pharmacology, Grace College of Pharmacy, Palakkad, Kerala, India

bijovilaventgu@gmail.com (Primary Contact)

Bijo Mathew

Department of Pharmaceutical Chemistry, Grace College of Pharmacy, Palakkad, Kerala, India

Sajeeth C.I.

Department of Pharmaceutics, Grace College of Pharmacy, Palakkad, Kerala, India

Githa Elizabeth Mathew, Bijo Mathew, & Sajeeth C.I. (2011). Phytochemical evaluation and lipid lowering property of leaves of Vitex negundo linn. in hyper cholestremic rats. International Journal of Research in Pharmaceutical Sciences, 2(1), 18–22. Retrieved from https://ijrps.com/home/article/view/3028

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